Ophthalmic Science and Engineering Lab
Prof. Yossi Mandel
Electrical Stimulation of the Isolated Retina
Here is a threshold investigation of 4 weeks old GCaMP6f-RCS rat.
Hybrid Retinal Prosthesis
We are developing a hybrid retinal implant composed of high resolution electrode array integrated with glutamatergic neurons. The implant is aimed at restoration of sight with high visual acuity.
The glutamatergic cells are engineered from human Embryonic Stem Cells using advanced technologies for cells engineering.
Our research is supported by an ERC grant
Retinal implant in a rat eye.
See our publication in Current Biology
https://www.cell.com/current-biology/pdf/S0960-9822(19)31467-8.pdf
Interaction of Prosthetic Vision with Natural Vision
In patients blinded by photoreceptor degeneration, stimulation of the remaining retinal neurons can restore vision. We study various technologies and important neuroscience questions associated with retinal prosthesis.
In patients suffering from age-related macular degeneration who are implanted with retinal prosthesis. there is a unique combination of central prosthetic and peripheral normal vision. We are studying cortical processes associated with the combination of these two modalities using cutting end electrophysiology techniques. We further study visual plasticity processes associated with prosthetic vision.
Collaborator: Prof. Daniel Palanker, Stanford University
Stem cells engineering for vision restoration
We are engineering human embryonic stem cells into photoreceptors and retinal pigment epithelium (RPE) cells to restore retinal function in retinal degeneration diseases.
Nano-ophthalmology - Nanotechnology for drug delivery - for AMD therapy and more
We are developing novel treatment for application of anti-vascular agents in cases of age-related macular degeneration (AMD) aimed at replacing injections with topical treatment. Other applications of nanotechnology are developed such as - tracing transplanted cells.
Temporal resolution of the visual system
We are studying the temporal resolution of the visual system in normal and amblyopic eye and focus on enhancement and integration of bnocular information
Novel technologies for gene therapy
We are studying various approaches for non-vital gene delivery system in the eye.
Blood loss from femoral and mesenteric artery injury with and without electric pulse treatment
Electrical Stimulation of the Autonomic Nervous System
We are studying the effect of electric pulse stimulation on the sympathetic nervous system.
click for a video
We are now studying the effect of intravascular application of electric field via endovascular catheterization, as is described in our recent publication.